Effect of Abdominal Lymphatic Pump Treatment on Disease Activity in a Rat Model of Inflammatory Bowel Disease
Context: Inflammatory bowel disease (IBD), such as ulcerative colitis and Crohn disease, are chronic relapsing inflammatory diseases that affect 1.5 million people in the United States. Lymphatic pump treatment (LPT) techniques were designed to enhance the movement of lymph and can be used to relieve symptoms in patients with IBD and other gastrointestinal disorders.
Objective: To determine whether LPT would decrease gastrointestinal inflammation and reduce disease severity in rats with acute IBD.
Methods: On day 0, rats were randomized into control or experimental groups. Control rats received normal drinking water for days 0 to 9. On days 0 to 9, rats in the experimental groups received drinking water containing 3.5% dextran sodium sulfate (DSS).
Conclusion: Abdominal LPT marginally improved disease severity in rats with mild IBD. To identify the optimal effect of LPT on IBD, future studies should include animals with more severe acute and chronic IBD. Considering the growing use of adjunctive treatment for the management of IBD, it is important to identify the effect of OMT on IBD progression. Studies such as these are important for identifying the mechanism of action of OMT during the treatment of IBD.
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